Genetic Association Studies of Copy-Number Variation: Should Assignment of Copy Number States Precede Testing?
نویسندگان
چکیده
منابع مشابه
Genetic Association Studies of Copy-Number Variation: Should Assignment of Copy Number States Precede Testing?
Recently, structural variation in the genome has been implicated in many complex diseases. Using genomewide single nucleotide polymorphism (SNP) arrays, researchers are able to investigate the impact not only of SNP variation, but also of copy-number variants (CNVs) on the phenotype. The most common analytic approach involves estimating, at the level of the individual genome, the underlying num...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034262